Two sample MR report
CLEC12A_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | -0.0156485 | 0.1256776 | 0.9031556 |
| Weighted median | 13 | -0.0660639 | 0.0240047 | 0.0059210 |
| Inverse variance weighted | 13 | -0.0564297 | 0.0194453 | 0.0037082 |
| Simple mode | 13 | -0.0681196 | 0.0404378 | 0.1178833 |
| Weighted mode | 13 | -0.0669867 | 0.0375751 | 0.0999225 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.044648 | 11 | 0.9685927 |
| Inverse variance weighted | 4.152525 | 12 | 0.9805241 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0205911 | 0.0626924 | 0.748742 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003689 | 0 | TRUE | 0.0676848 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
